The Derrynaflan Chalice is an 8th- or 9th-century chalice that was found as part of the Derrynaflan Hoard of five liturgical vessels. The discovery was made on 17 February 1980 near Killenaule, County Tipperary in Ireland. According to art historian Michael Ryan the hoard "represents the most complex and sumptuous expression of the ecclesiastical art-style of early-medieval Ireland as we know it in its eighth- and ninth-century maturity." The area known as Derrynaflan is an island of pastureland surrounded by bogland, which was the site of an early Irish abbey. The chalice was found with a composite silver paten, a hoop that may have been a stand for the paten, a liturgical strainer and a bronze basin inverted over the other objects. The group is among the most important surviving examples of Insular metalwork. It was donated to the Irish State and the items are now on display in the National Museum of Ireland.

The hoard was probably secreted during the turbulent 10th to 12th centuries, when Viking raids and dynastic turmoil created many occasions when valuables were hidden. The early and later 10th century is marked by a particular concentration of hoarding in Ireland.